It’s been almost 12 years and three Presidential terms since Bill Clinton left the White House. Listening to his closing keynote at last week’s Entrepreneur 2012 London summit, it was clear to see why he left his post with the highest end-of-office approval rating of any U.S President since World War II.

Talking to a packed ExCel crowd of 4,000 would-be and successful entrepreneurs, Clinton demonstrated his disruptive entrepreneur credentials through personal success stories of corporate reform. Rather than take on the business elite, he has worked with them to leverage humanitarian change that benefited the disadvantaged and turned an economic profit for multi-national organisations.

Here are five memorable takeaways from his talk:

1. Always be on the look out for unique opportunities in a downturn. If you can’t find a solution to a problem, you are looking at the wrong problem.

2. Territorial walls are becoming nets. Working in a progressive network is the key to turning good intentions into real change.

3. We live in amazing times. Clinton suggested he would give up having been president to be 20 years old and charting a course through the next generation.

4. We are great at solving yesterday’s problems. Our private and public sector leaders of the future will be the ones who embrace a global entrepreneurial approach to the political challenges and economic opportunities of climate change.

5. Our world is too unequal, too unstable, too unsustainable. Collaboration through technology is the key to prospering turning good eco intentions into real change.

With 100 million attendees in over 100 countries attending a Global Entrepreneur Week event, it's possible Bill Clinton will be around long enough to witness this change and still get to keep his Commander-in-Chief place in history.